Jo-1 Ab

Keywords: Jo-1 antibody, Histidyl-tRNA synthetase antibody

Specimen:

5 mL blood in plain tube.

Method:

Immunoassay, electrophoresis and line blot.

Reference Interval:

Qualitative test.

Application:

Diagnosis of Polymyositis.

Interpretation:

The presence of Jo-1 antibodies defines a subset of Polymyositis with associated Interstitial lung disease. It is present in a small proportion of patients with Polymyositis alone.

Autoantibodies against other t-RNA synthetases are also found in association with Polymyositis.

Reference:

Imbert-Masseau A. Joint Bone Spine. 2003; 70(3): 161-168.