L-Lactate

Keywords: Lactate

Specimen:

5 mL blood in fluoride tube.

A lithium heparin tube can be used if plasma is separated and frozen immediately.

Method:

Spectrophotometry, lactate-specific electrode.

Reference Interval:

Fasting arterial blood: 0.3-0.8 mmol/L.

Fasting venous blood: 0.3-1.3 mmol/L.

Application:

Investigation of metabolic acidosis with an increased anion gap.

Interpretation:

Lactate levels may be increased in association with Diabetes mellitus, Shock, hypoxia, congestive heart failure, and in numerous other pathological states and metabolic disorders.

Lactic acidosis in children may have a genetic origin.

Lactic acidosis may be seen during treatment of HIV with nucleoside analogues.

See also Pyruvate.

Reference:

De Backer D. Minerva Anestesiol. 2003; 69(4): 281-284.

Falco V et al. Expert Opin Pharmacother. 2003; 4(8): 1321-1329.