Leptospira Ab

Keywords: Leptospira antibody, Leptospira sp antibody, Leptospira species antibody, Leptospiral serology

Specimen:

5-10 mL blood in plain tube, acute and convalescent specimens required.

Method:

Microagglutination, EIA.

Application:

Investigation of suspected leptospirosis (eg, fever, hepatitis, renal failure).

Interpretation:

IgM is detectable by EIA within the first week of the disease. Since it may persist for many months IgG seroconversion is required to confirm a diagnosis of recent infection.

A four-fold rise in microagglutination titre, or a titre of ≥800, in a suggestive clinical setting is strong evidence of infection.

Microagglutination serology can be used to identify the serovar likely to be causing infection.

Reference:

Winslow WE et al. J Clin Microbiol .1997; 35: 1938-1942.