Lung biopsy

Specimen:

Fine needle aspiration biopsy, bronchial/transbronchial, transthoracic needle biopsy, open lung, lobectomy and pneumonectomy specimens. 

Specimens requiring culture should be submitted fresh, as should larger specimens requiring fixation by inflation.

Method:

Fresh tissue: frozen section, microbiological examination, (bacterial, fungal and myobacterial microscopy and culture if indicated) molecular genetics.

Fixed tissue: light microscopy, immunohistochemistry, electron microscopy (special fixative).

Application:

May be indicated in the investigation of: pneumonias (infective and non-infective), allergic and granulomatous disease, pulmonary fibrosis, pulmonary hypertension, vasculitis, pneumoconiosis and tumours.

Interpretation:

Categorisation and prognosis of alveolar and interstitial pneumonias;

identification of infecting organisms;

typing of granulomatous disease including sarcoid;

diagnosis of primary and systemic vascular disorders;

typing of pneumoconiosis and identification of complications; and

identification of tumour type, grade and stage.

Reference:

Corrin B Pathology of the lungs. 3rd ed Churchill Livingston 2011.