Lupus band test

Specimen:

Biopsy of normal, non-sun-exposed skin and of affected skin.

Specimens should not be placed in fixative and should be transported rapidly to the laboratory on moist gauze.

Method:

Direct IF.

Application:

Diagnosis of systemic lupus erythematosus (SLE).

Interpretation:

Immunoglobulin and C3 deposition at the dermo-epidermal junction of both lesional and normal skin is seen in SLE, whereas deposition in lesional, but not normal, skin occurs in discoid lupus.

Sensitivity for SLE is 60%. Relatively specific for SLE, however any form of skin damage may cause basement membrane deposition of immunoglobulin.

Reference:

Harris TJ et al. Arthr Rheum. 1980; 23: 479-490.