Malaria Ag

Keywords: Malaria antigen

Specimen:

5 mL blood in EDTA; 2 mL blood in special paediatric EDTA tube.

Method:

Antigen detection by immunochromatography.

Application:

As an adjunct to blood film microscopy for the diagnosis of malaria.

Testing is rapid and simpler to perform and interpret than thick and thin films, but is insufficiently sensitive to be used as a substitute.

Interpretation:

The Plasmodium species that can be detected depend on the specific test used. Some tests detect only Plasmodium falciparum. For tests that detect more than one species, the sensitivity is not equal for all of the species. Mixed infections may be missed.

A positive result indicates malarial infection. However, positive results may persist for three or more weeks after successful therapy. False negatives occur. The test is not quantitative and cannot indicate the stages of malarial parasite present.

Reference:

Wongsrichanalai C et al. Am J Trop Med Hyg. 2003; 69: 26-30.

Iqbal J et al. J Clin Microbiol. 2002; 40: 4675-4678.