NMDA receptor Ab

Keywords: NMDA receptor antibody

Specimen:

5 mL blood in plain tube or 1 mL CSF.

Method:

Indirect immunoflorescence using tissue or transfected cells.

Reference Interval:

Method dependent

Application:

Diagnosis of NMDA receptor antibody mediated encephalitis.

Interpretation:

A positive result is highly suggestive of antibody mediated encephalitis. Absence of antibody in serum does not exclude NMDA receptor antibody mediated encephalitis as antibody is frequently only able to be detected in CSF.

Reference:

Peery HE et al. Anti-NMDA receptor encephalitis. The disorder, the diagnosis and the immunobiology. [Review] Autoimmunity Reviews. Oct 2012. 11(12):863-72.