NT-proBNP

Keywords: N terminal pro-brain natriuretic peptide level, NT-proBNP

Specimen:

5 mL blood in EDTA tube.

Method:

Immunoassay.

Reference Interval:

< 300 ng/L

Application:

Diagnosis and assessment of severity of heart failure.

Interpretation:

NT-proBNP < 300 ng/L Congestive heart failure (CHF) unlikely.

Consistent with the diagnosis of CHF

Age < 50 years NT-proBNP > 450 ng/L

Age 50-70 years NT-proBNP > 900 ng/L

Age > 70 years NT-proBNP > 1800 ng/L

NT-proBNP has a longer half-life than BNP. Circulating levels are similar to BNP in normal individuals, but are significantly more elevated by left ventricular dysfunction than BNP.

NT-proBNP levels may be elevated by factors other than CHF, such as acute coronary syndrome, pulmonary embolism, shock, atrial arrhythmia, severe pneumonia and renal disease.

NT-proBNP levels are higher in women than men, increase with age and have an inverse relationship with BMI (lower in obesity).

Reference:

Januzzi JL. Eur Heart J. 2006; 27: 330.

2013 ACCF/AHA Guideline for the Management of Heart Failure
A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 2013; 128: e240-e327