Oesophageal biopsy

Specimen:

Endoscopic biopsy specimen.

Method:

Separate containers should be used for each biopsy from different sites. 

Ideally the biopsy should be placed on to a small square of paper, orientated with the mucosa exposed and placed in formalin fixative. 

Light microscopy, histochemistry, immunohistochemistry.

Application:

Investigation of symptoms of reflux and dysphagia, acute and chronic oesophagitis, oesophageal polyp, Barrett's oesophagus, and surveillance of oesophageal dysplasia, malignancy.

Interpretation:

Report by pathologist identifies nature of lesion sampled. 

In case of tumours type, grade and stage is reported.

Reference:

Montgomery, E. Biopsy interpretation of Gastrointestinal Tract Mucosa. Vol 1 and 2. 2012 (2nd Ed) Lippincott, Williams and Wilkins.