Osteocalcin

Specimen:

5 mL blood in a plain tube.

Method:

Immunoassay.

Reference Interval:

10-40 µg/L.

Application:

The serum level reflects the extent of laying down of bone matrix. Thus, it is potentially useful in disorders where this is abnormal or is changed by therapy. However, serum PINP is the preferred formation marker and plasma CTX, the preferred resorption marker in Osteoporosis and in metastatic bone disease. Serum PINP or B-ALP are preferred formation markers and urine NTX the preferred resorption marker in Paget's disease of the bone.

It has been used to monitor the treatment of Osteoporosis and of Paget's disease of the bone, although replaced by other markers as above.

Interpretation:

Appropriate changes in levels indicate successful response to therapy.

Reference:

Gundberg CM. Clin Lab Med. 2000; 20(3): 489-501.