Parathyroid hormone

Keywords: PTH, Parathyroid hormone intact, Intact parathyroid hormone

Specimen:

10 mL blood in plain tube. Specimen transported rapidly to laboratory on melting ice.

Method:

Immunoassay.

Reference Interval:

1.0-7.0 pmol/L (method dependent).

Application:

Investigation of unexplained hypercalcaemia and hypocalcaemia.

Monitoring management of osteodystrophy in chronic renal failure.

Interpretation:

The interpretation of PTH levels is dependent on the patient’s corrected calcium, or ionised calcium, at the time the blood specimen was taken.

In hyperparathyroidism the PTH level is increased or high normal in the presence of hypercalcaemia.

In most cases of hypercalcaemia associated with malignancy PTH level will be suppressed, often with an elevated PTHrP.

Hypoparathyroidism is associated with a low PTH.

Pseudohypoparathyroidism and other causes of hypocalcaemia are associated with a high PTH.

Effective management of osteodystrophy in chronic renal failure is associated with relatively little or no elevation of PTH.

See also Parathyroid hormone related protein.

Reference:

St John A. Clin Biochem Rev 1995; 16: 27-36.