Parietal cell Ab

Keywords: Parietal cell antibody

Specimen:

10 mL blood in plain tube.

Method:

Indirect IF.

Reference Interval:

Not detected.

Application:

A supportive, but not diagnostic, test for pernicious anaemia.

Interpretation:

Antibodies react with sub-units of the gastric parietal cell proton pump.

Positive in 80% of patients with pernicious anaemia and in 40-50% of patients with other organ specific autoimmune diseases.

See Intrinsic factor Ab.

Reference:

Yao Y et al. J Fam Pract. 1992; 35: 524-528.