Parvovirus B19 Ab

Keywords: Parvovirus B19 antibody

Specimen:

10 mL blood in plain tube.

Method:

EIA.

Application:

Investigation of aplastic crisis in chronic haemolysis;

transient erythroblastopenia of childhood;

anaemia with or without neutropenia in immunosuppressed patients;

maternal infection associated with hydrops fetalis, subacute polyarthritis or suspected fifth disease (erythema infectiosum).

Interpretation:

IgM antibodies provide evidence of recent parvovirus infection.

IgG levels fluctuate, so rising titres may not indicate recent exposure.

Diagnosis of persistent infection requires detection of virus by nucleic acid probe after PCR amplification (specialised laboratories only).

Reference:

Heegaard ED et al. Clin Microbiol Rev. 2002; 15: 485-505.