Phenobarbitone

Keywords: Phenobarb, Phenobarbital, Methyl phenobarbitone

Specimen:

5 mL blood in plain tube.

Method:

Chromatography, immunoassay.

Therapeutic Interval:

65-170 µmol/L (15-40 mg/L).

Application:

Therapeutic drug monitoring of phenobarbitone or primidone.

Interpretation:

Phenobarbitone has a long half-life and a steady state may not be reached for several weeks.

Mean half-life is 100 h (range 50-150 h).

Primidone is metabolised to phenobarbitone.

Reference:

Glauser TA and Pippenger CE. Epilepsia 2000; 41(8): 6-15.