Plasminogen

Description:

This assay is rarely performed and only in specialised laboratories.

Specimen:

4.5 mL blood in 0.5 mL citrate.

Method:

Functional or immunoassay.

Reference Interval:

50-150%.

Application:

Investigation of tendency to venous thromboembolism; recurrent, unexplained, or with positive family history.

Interpretation:

Plasminogen levels are low in full-term infants and plasminogen may be undetectable in premature neonates.

Congenital deficiency has not been described. Inherited plasminogen variants are associated with an increased incidence of thrombosis.

Decreased levels may be found in liver disease. Increased levels occur in pregnancy, women on the oral contraceptive pill.

Levels increase with age and are higher in Africans than Caucasians.

Reference:

Bain et al. Dacie and Lewis Practical Haematology. 11th Ed. 2012.