Protein urine

Keywords: Urine protein, Urine Pr, Protein excretion

Specimen:

Random urine specimen or 24 h urine collection.

Method:

Spectrophotometry.

Reference Interval:

< 150 mg/24 h; pregnancy: < 250 mg/24 h.

Application:

Assessment of renal disease. Some methods will not detect light chain proteinuria; see Protein electrophoresis urine.

Interpretation:

Protein loss in the urine is most commonly due to renal glomerular disease, esp if > 2 g/24 h. Proteinuria of > 3 g/24 h is required to establish the diagnosis of the Nephrotic syndrome. In renal tubular disease, light chain proteinuria, orthostatic proteinuria and myoglobinuria, protein loss is usually < 1 g/24 h.

See also Urinalysis.

Reference:

Beetham R and Cattell WR. Ann Clin Biochem 1993; 30: 425-434.