Pyruvate

Specimen:

Specimen collection requirements should be discussed with the laboratory. Tourniquet use should be avoided.

Method:

Spectrophotometry.

Reference Interval:

0.03-0.10 mmol/L.

Application:

Classification of genetic lactic acidosis, differentiating primary pyruvic acidaemia from lactic acidaemia.

Interpretation:

Elevated lactate/pyruvate ratio indicates primary lactic acidosis.

Normal lactate/pyruvate ratio indicates primary pyruvic acidosis (eg, pyruvate dehydrogenase deficiency).

Reference:

De Meirleir L. J Child Neurol. 2002; 17: 26-34.