Q Fever Ab

Keywords: Q fever antibody, Q fever serology, Coxiella burnetti antibody

Specimen:

Specimen: 5-10 mL blood in plain tube at onset and 2-3 weeks after onset of illness.

The request form should indicate the purpose of the testing (eg, pre-vaccination screening, possible acute infection or chronic Q fever infection, since different tests are used for each of these).

Method:

CFT, IFA, EIA.

Application:

Diagnosis of suspected Q fever, atypical pneumonia, hepatitis of unknown cause or blood culture-negative endocarditis.

Occupational health screening of abattoir and livestock workers at commencement of employment or after vaccination.

If chronic Q fever is suspected (eg, endocarditis) antibodies to phase I antigen should be specifically requested.

Interpretation:

Infection with Coxiella burnetii stimulates antibodies to both phase I and phase II antigens.

In acute Q fever, antibodies to phase II antigen are detectable 1-2 weeks after onset of the illness and peak between 4 and 12 weeks.

Recent infection is confirmed by a four fold rise in titre or a positive IgM test. A single CFT titre of > 8 for antibodies to phase II antigen indicates past infection.

Antibodies to phase I antigen are only present in significant titre in chronic Q fever (eg, endocarditis or granulomatous liver disease).

Reference:

Maurin M and Raoult D. Clin Microbiol Rev 1999; 12: 518-553.

Field PR iet al. J Clin Microbiol. 2002; 40: 3526-3529.