Rickettsial Ab

Keywords: Rickettsial antibody, Rickettsial serology

Specimen:

5-10 mL blood in plain tube. Acute and convalescent samples.

Method:

IF.

Application:

Confirmation of a clinical diagnosis of typhus (murine or scrub) or spotted fever (including Queensland tick typhus and Flinders Island spotted fever).

Interpretation:

The diagnosis of rickettsial infection is confirmed by a four-fold rise in antibody titre between acute and convalescent samples.

The traditional Weil-Felix test, based on the pattern of serological reactions to Proteus spp, lacks sensitivity and specificity and is no longer recommended.

Reference:

Graves SR. Pathology 1998; 30: 147-152.

Baird RW et al. J Clin Microbiol 1992; 30: 2896-2602.