Uterine cervix biopsy

Specimen:

Punch or excision biopsy, biopsies from electrosurgical excision loop procedure (LEEP) or large loop excision of transformation zone (LLETZ), cone biopsy.

Method:

Fixed tissue in 10% buffered formal saline.

Application:

Investigation of abnormal smears. 

Diagnosis of HPV and other cervical infections. 

Assessment of epithelial hyperplasia and metaplasia, grading of epithelial dysplasia (CIN), diagnosis of invasive malignancy.

Interpretation:

Report by pathologist identifies the nature of the lesion sampled. 

Tumour type, grade and stage are reported for neoplasms.

Reference:

Kurman J in Kurman J ed. Blaustein's Pathology of the Female Genital Tract. 6th ed. 2011. Springer.