White cell count

Keywords: White blood cell count, WCC, WBC, WBC Diff, Differential, Leucocyte count, Leucocyte differential count

Specimen:

5 mL blood in EDTA.

2 mL blood in special paediatric EDTA tube.

Method:

Part of Full blood count; all nucleated cells (leucocytes + nucleated red cells if present)  counted.

The count is corrected for nucleated red cells if present.
Reference Interval:

Refer to laboratory reference range.

Neonate: 6.0-22.0 x 10^9/L

Child:
1 year: 6.0-18.0 x 10^9/L 
4-7 years: 5.0-15.0 x 10^9/L
8-12 years: 4.5-13.5 x 10^9/L

Application:

Possible infection, inflammatory disease, immune disease, bone marrow failure, haematological or other malignancy.

Monitoring drugs with potential or predictable bone marrow toxicity.

Interpretation:

Depends on white cell differential. See White cell count differential.

Reference:

Bain BJBlood cells: a practical guide. 4th Ed. 2007. Oxford: Blackwell Publishing.