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Normal and Benign Changes

Squamous – normal, inflammatory, atrophy

The appearance of non-neoplastic squamous cells in LBC preparations differs little from that in CP. Nuclear shape and size remain consistent in benign repair and nucleoli are present and uniform. In atrophy, parabasal cells may appear singly while basal cells present in flat sheets.

ThinPrep® - Negative

ThinPrep® - Negative

Superficial and Intermediate squamous cells

ThinPrep® - Atrophy

ThinPrep® - Atrophy

Basal and parabasal cells are well preserved and appear in loose sheets and singly

ThinPrep® - Repair

ThinPrep® - Repair

Nuclei are regular in shape and size and nucleoli are small and uniform

SurePath™ - Negative

SurePath™ - Negative

Superficial and Intermediate squamous cells

SurePath™ - Atrophy

SurePath™ - Atrophy

Parabasal cells are distributed singly and basal cells appear in loose sheets

SurePath™ - Repair

SurePath™ - Repair

Cells appear in a flat sheet with uniform nuclear size and shape and small, prominent nucleoli

Endocervical – normal, inflammatory, atrophy

As with squamous cells, the appearance of benign endocervical cells in LBC preparations differs little from that seen in CP. Because of the different slide preparation method, SP slides may contain more large groups of endocervical cells than TP however smaller groups and strips as well as single cells are represented well in LBC preparations. Reactive endocervical cells show enlarged nuclei with vesicular chromatin and prominent nucleoli and cytoplasmic vacuolation may be more clearly seen than in CP.

SurePath™ - Endocervical cells

SurePath™ - Endocervical cells

Sheet of endocervical cells showing honeycomb arrangement

SurePath™ - Endocervical cells

SurePath™ - Endocervical cells

Normal and reactive endocervical cells in small sheets

SurePath™ - Reactive endocervical cells

SurePath™ -  Reactive endocervical cells

Nuclei are enlarged and nucleoli are prominent
 

ThinPrep® - Endocervical cells

ThinPrep® - Endocervical cells

Sheet of endocervical cells showing regular, round-to-oval nuclei with smooth nuclear membranes and inconspicuous nucleoli

ThinPrep® - Endocervical cells

ThinPrep® - Endocervical cells

Large sheet of endocervical cells showing honeycomb pattern and cytoplasmic vacuoles

ThinPrep® - Endocervical cells

ThinPrep® - Endocervical cells

Small group of endocervical cells with cytoplasmic vacuoles

Endometrial - normal, benign

Endometrial cells in LBC preparations may appear as three-dimensional groups instead of the flattened and folded sheets seen in CP. Nuclei are small and kidney-shaped and chromocentres may appear more prominent. Epithelial and stromal cells can be differentiated.

ThinPrep® - Endometrial cells

ThinPrep® - Endometrial cells

3-D group of endometrial cells

SurePath™ - Endometrial cells

SurePath™ - Endometrial cells

Small group of endometrial cells showing 3-D arrangement