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Details of Gene

Item Details
Gene/Locus name

DICER1 (also called Dicer,KIAA0928,K12H4.8-LIKE,HERNA)

Long Name

dicer 1, ribonuclease III (OMIM 606241)

Associated Disorders

OMIM 601200 : Pleuropulmonary blastoma
OMIM 180295 : Rhabdomyosarcoma, embryonal, 2
OMIM 138800 : Goiter, multinodular 1, with or without Sertoli-Leydig cell tumors

Interpretation / Comment

Laboratory methods do not necessarily identify all of the clinically significant variants in a gene. The failure to identify a variant does not necessarily mean that the gene is normal. Variants in a gene may cause more than one disease, and the identification of a clinically significant variant does not necessarily indicate the specific disease that the patient or relatives may be at risk of developing. Conversely, the disease/s associated with a gene might also be caused by mutations in other genes, and the failure to identify a clinically significant variant in one gene does not necessarily alter the clinical diagnosis or risk for relatives.

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