Platelet Ab

Keywords: Platelet antibody


Only performed in specialised laboratories.

10 mL EDTA blood for Direct tests (PAIg) and 10 mL plain clot for Indirect. Less for paediatrics by negotiation.


IF, Flow cytometry, MAIPA, Luminex Xmap technology.

Variously used to demonstrate platelet autoantibodies, drug-dependent antibodies, alloantibodies.

Platelet aggregation for heparin-dependent antibodies (HIT).


Used in the investigation of immune thrombocytopenias: ITP, drug-induced thrombocytopenia (including HIT), post-transfusion purpura and neonatal thrombocytopenia.

Investigation of refractoriness to platelet transfusion - usually after testing for HLA antibodies and trial of HLA-compatible or HLA-matched platelets.


Lochowitz A.J. et al. LabMedicine. 2011; 42, 687-692.

Curtis B.R. et al. Immunohematology. 2009; 25, 125-135