Causes Appropriate Tests

The acute episode is an emergency, which must always be treated urgently.

Blood should be collected and stored for testing, including Complement components C3 and C4. Tryptase to confirm anaphylaxis, if indicated.

Subsequent investigation is required to establish cause: Skin prick allergen test with suspected allergens or Allergen specific Immunoglobulin E to detect specific IgE to relevant agents; Interval tryptase, if recurrent.

See also Angioedema, Urticaria.

Drugs, especially


  • Antibiotics in particular cephalosporins


  • NSAID including aspirin


  • General anaesthetic agents

Therapeutic/biological products, especially


  • Blood transfusion, including

Immunoglobulin A to exclude selective IgA deficiency.

  • Blood component therapy


  • Allergen desensitisation


  • Insect stings

See Insect sting sensitivity.

  • Contrast agents

See Anaphylactoid reaction.

Food and other ingestants, especially


  • Egg


  • Milk


  • Fish


  • Peanuts


  • Shellfish


  • Other nuts


Contactants, especially


  • Latex

See Latex allergy.

  • Diethyl-meta-toluamide

Present in insect repellants.

  • Bacitracin/neomycin






Anaphylactoid reaction

A term used when the clinical presentation is that of anaphylaxis, but an Allergen specific Immunoglobulin E cannot be demonstrated.


Ingrid Laemmle-Ruff. Australian Family Physician. Vol. 42, No.1, January/February 2013; pg 38-42

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