Bullous skin lesions


Appropriate Tests

Solar/thermal injury

Diagnosis based on history and physical examination, with selected diagnostic imaging, endoscopy and pathology tests, as indicated.

Contactants, including

  • Rhus tree
  • Grevillea (Robyn Gordon type)
  • Poison ivy
  • Chemicals

Patch testing is sometimes indicated. It should only be performed by a specialist practitioner, as reactions may be severe.

Bullous impetigo


Herpes simplex virus infection


Varicella zoster infection



Pemphigus Ab.


Pemphigoid Ab.

Erythema multiforme


Porphyria, especially

  • Porphyria cutanea tarda
  • Porphyria variegata


Porphyrins urine.
Porphyrins urine, Porphobilinogen urine, Porphyrins faeces.



Epidermolysis bullosa

Molecular genetics, if available.

Dermatitis herpetiformis

Transglutaminase Ab.

See also Coeliac disease.

Staphylococccal scalded skin syndrome

Clotted blood for TSST-1 analysis in specialist laboratory.

Toxic epidermal necrolysis


Graft versus host disease


Fixed drug reactions, especially

  • Tetracycline



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