The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Hydatidiform moles may be partial or complete (classical).
Virtually all complete hydatidiform moles have a diandric paternal-only genome with 46, XX diploid karyotype from fertilisation of an empty ovum by one spermatozoon (90%) or 46 XX or XY from fertilisation of an empty egg simultaneously by 2 spermatozoa (10%). Partial moles are triploid and result from fertilisation of a normal ovum by 2 heterozygous spermatozoa (90%) or 1 spermatozoon with duplication (10%). Although assessment of whether the genotypic profile is homozygous or heterozygous should distinguish between 90% of complete or partial moles, molecular genetic testing is not routinely undertaken.
The diagnosis is suggested by clinical features, diagnostic imaging and increased Human chorionic gonadotrophin (beta subunit) levels (Beta HCG quantitation).
Histological assessment of aborted or curetted material is confirmatory.
Serial beta human chorionic gonadotrophin estimations (Beta HCG quantitation) for up to 12 months are recommended, to confirm complete removal and/or detect recurrence.
Bifulco et al. Am J Surg Pathol 2008; 32: 445-51.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
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