Key Information

Appropriate Tests


Paraproteinaemia in which the monoclonal protein is IgM.

Protein, Albumin, Protein electrophoresis, Paraprotein typing, Immunoglobulins G, A, M; Full blood count, Blood film, White cell count differential, Erythrocyte sedimentation rate, Free light chains.

See also Paraproteinaemia

'Benign' disorders


  • Cold haemagglutinin disease

See Autoimmune haemolysis (idiopathic 'cold' antibody haemolysis).

B lymphoplasmacytic and lymphocytic neoplasms

Bone marrow aspiration and trephine biopsy, Lymph node biopsy, as indicated. Lymphocyte immunophenotyping on blood, Bone marrow aspirate, Lymph node biopsy material, as appropriate.

See also Hyperviscosity syndrome

  • Waldenström's macroglobulinaemia


  • Lymphoma (non-Hodgkin)


  • Chronic lymphocytic leukaemia


  • Monoclonal gammopathy of undetermined significance


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