The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
Donate online now using the button below. RCPA Foundation thanks you for your generous support. All funds raised will be allocated to the RCPA Foundation Pathology Education Outreach Fellowship.
Events and Sponsorship Manager
Ph: +61 2 8356 5806
Fax: +61 2 8356 5828
Events and Grants Coordinator
Ph: +61 2 8356 5852
Fax: +61 2 8356 5828
Full blood count, Blood film: macrocytosis (may be extreme in severe vitamin deficiency), single, dual or pancytopenia; oval macrocytes, hypersegmented neutrophils). Vitamin B12 and Folate assays.
Elevated Bilirubin and Lactate dehydrogenase are due to haemolysis, including intramedullary haemolysis.
Bone marrow aspiration rarely required to confirm diagnosis.
Review clinical findings to guide investigation of cause.
See also Anaemia
Vitamin B12 deficiency
See Folate deficiency, Vitamin B12 deficiency for drugs interfering with absorption.
Inhibition of folate metabolism, especially
In susceptible individuals.
Inactivation of vitamin B12
Prolonged exposure, especially anaesthetists.
Inhibition of pyrimidine, purine synthesis, DNA assembly
Inborn errors of metabolism
Rare - consult pathologist.
Page last updated:
The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
Copyright © 2020 RCPA. All rights reserved.