Myeloproliferative neoplasms

Keywords: MPN, Myeloproliferative disorders

Key Information

Appropriate Tests

A group of related, clonal, stem cell disorders characterised by excessive production of erythrocytes and/or granulocytes and/or platelets, increased bone marrow fibrosis, splenomegaly and, often, hyperuricaemia.

They all have the potential for transformation to acute leukaemia. Please see individual clinical problem entries as listed below.

Myeloproliferative neoplasms (MPN) have been subclassified by the World Health Organization as follows:

See also Chronic leukaemia

Please see individual clinical problem entries as listed below:


Chronic myeloid leukaemia


Polycythaemia vera


Essential thrombocythaemia (ET)


Primary myelofibrosis


Chronic eosinophilic leukaemia


Chronic neutrophilic leukaemia


Atypical chronic myeloid leukemia


Chronic myeloproliferative disease - unclassifiable


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