Appropriate Tests


Review clinical features, Full blood count, Blood film, White cell count differential, Immunophenotyping.

See also Table 4; Neutrophilia with early myeloid cells.


  • Physical stress/vigorous exercise
  • Emotional stress
  • Pregnancy


Infection, especially

  • Bacterial
  • Rickettsial diseases
  • Viral (occasionally) eg, Chicken pox, Herpes simplex virus infection

Microscopy and culture of local lesion, body fluid, or blood, as appropriate.

Other inflammation, especially

  • Connective tissue diseases
  • Rheumatoid arthritis
  • Still's disease
  • Polyarteritis nodosa


See Rheumatoid arthritis (juvenile)

Tissue necrosis, especially

  • Myocardial infarction
  • Carcinoma
  • Trauma
  • Surgery
  • Burns


Blood loss (acute)


Myeloproliferative neoplasms


Splenic atrophy/absence


Drug therapy, especially

  • Corticosteroids
  • Cytokines


Cytokines (eg, G-CSF, GM-CSF) commonly cause neutrophilia and/or monocytosis.

  • Clozapine


  • Lithium


Cigarette smoking


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