The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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A phaeochromocytoma is a catecholamine secreting tumour of the chromaffin cells from the adrenal medulla. A paraganglionoma is a catecholamine secreting tumour of chromaffin secreting cells from the sympathetic ganglia. These tumours are relatively rare with a prevalence of approximately 5 per million overall; ~0.5% of individuals with hypertension or ~5% of adrenal adenomas. They may also be familial occurring in Multiple endocrine neoplasia 2, Neurofibromatosis 2 and von Hippel-Lindau syndrome.
Initial screening for Phaeochromocytoma should include measurements of Free metanephrines and/or fractionated Metanephrines urine. Patient preparation is important and drug interferences should be considered when interpreting the results as they may cause false positive increases.
If indicated - Clonidine suppression test may be performed to further investigate borderline increases in plasma normetanephrine. Urine catecholamine measurements are less sensitive and not recommended.
If phaeochromocytoma is suspected, fine needle aspiration biopsy is contraindicated.
See also Multiple endocrine neoplasia (types 2A and 2B)
Eisenhofer G, Peitzsch M. Clin Chem 2014; 60: 1486-1499.
Eisenhofer G et al. Pharmacol Rev 2004; 5656: 331-349.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
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