The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
Donate online now using the button below. RCPA Foundation thanks you for your generous support. All funds raised will be allocated to the RCPA Foundation Pathology Education Outreach Fellowship.
Events and Sponsorship Manager
Ph: +61 2 8356 5806
Fax: +61 2 8356 5828
Events and Grants Coordinator
Ph: +61 2 8356 5852
Fax: +61 2 8356 5828
Polycythaemia can be relative (decreased plasma volume) or true polycythaemia. True polycythaemia can be primary (the myeloproliferative neoplasm Polycythaemia vera) or secondary (to states associated with appropriate or abnormal excessive erythropoietin.
Review clinical findings, including history of smoking and diuretic therapy.
Follow up Full blood count, Blood film, Erythropoietin.
The increased Hb / Haematocrit elevation is due to reduced plasma volume, eg, dehydration, diuretic therapy.
Stress polycythaemia (spurious polycythaemia)
Gaisböck syndrome, associated with smoking and alcohol use.
Erythropoietin (Epo) level may be useful: increased levels in secondary erythrocytosis, low to undetectable levels in Polycythaemia vera. Mutational analysis, ie, Jak-2 mutation can also be useful if present (in a proportion of Polycythaemia vera cases).
Blood gas arterial / Haemoximetry. See also Cyanosis.
See Cystic renal disease
See under Hypertension.
See under Renal mass.
See under Urinary tract obstruction.
Primary haematological disorder
High affinity haemoglobin
Haemoglobin oxygen affinity, Haemoglobin electrophoresis; Haemoglobin M; Pulse oximetry.
Review Full blood count, Blood film, Epo level, Jak-2 (and other relevant) mutations. Bone marrow aspiration and trephine biopsy may sometimes be useful in documenting other features of a myeloproliferative neoplasm (cytogenetic studies may show a clonal abnormality but there is not a single recurring abnormality characteristic of Polycythaemia vera).
Presence in vitro of the formation of spontaneous erythroid colonies (SECs) in the absence of Epo is a sensitive but not specific finding in Polycythaemia vera, and of limited availability.
A lower than normal range Epo level is of high diagnostic specificity for Polycythaemia vera.
Positivity for JAK-2 mutation confirms the presence of a myeloproliferative neoplasm but is not specific for Polycythaemia vera.
Page last updated:
The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
Copyright © 2021 RCPA. All rights reserved.