Testicular failure

Keywords: Gonodal hypofunction, Gondal hypofunction (male)


Appropriate Tests


Clinical assessment includes testicular site and size, evidence of androgen deficiency and of hypothalamic or pituitary disorder.

Semen analysis - fertility, Follicle stimulating hormone, Luteinising hormone, Prolactin, Testosterone, Testicular biopsy is rarely appropriate.

See also Infertility (male and female)

Hypogonadotrophic hypogonadism (hypothalamic/pituitary disorders)


Gonadotrophin releasing hormone deficiency (Kallmann syndrome)



See under Hypopituitarism



Hereditary haemochromatosis


Hypergonadotrophic hypogonadism (primary testicular disorders)


Chromosome abnormalities

Cytogenetics - constitutional.

  • Klinefelter syndrome




Bilateral anorchia


Noonan syndrome


Vanishing testis syndrome


Acquired testicular failure


  • Trauma - thermal/physical


  • Varicocoele

Usually eugonadotrophic.

  • Cirrhosis


  • Renal failure


  • Cytotoxic drugs/irradiation


  • Viral orchitis

History of Mumps, or other viral infection, associated with Orchitis.

  • Myotonic dystrophy

See under Muscular dystrophy

  • Autoimmune

Sperm Ab.

Go Back

Page last updated:

Copyright © 2021 RCPA. All rights reserved.