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Diagnosis and classification of vasculitis is based on the findings at biopsy of the affected tissue/organ, together with the clinical picture and the results of Antineutrophil cytoplasmic Ab (ANCA).
Extent of disease is assessed by diagnostic imaging; Creatinine, Urea, Alkaline phosphatase, Aspartate aminotransferase, Alanine aminotransferase, Gamma glutamyltransferase.
Activity of disease is evaluated by C-Reactive protein, Erythrocyte sedimentation rate, occasionally Complement components C3 and C4.
Investigation for the underlying cause may include Rheumatoid factor, Cryoglobulins, Protein electrophoresis, Antinuclear Ab, Hepatitis B serology, Hepatitis C serology, and HIV testing.
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