Appropriate Tests


Diagnosis and classification of vasculitis is based on the findings at biopsy of the affected tissue/organ, together with the clinical picture and the results of Antineutrophil cytoplasmic Ab (ANCA).

Extent of disease is assessed by diagnostic imaging; Creatinine, Urea, Alkaline phosphatase, Aspartate aminotransferase, Alanine aminotransferase, Gamma glutamyltransferase.

Activity of disease is evaluated by C-Reactive protein, Erythrocyte sedimentation rate, occasionally Complement components C3 and C4.

Investigation for the underlying cause may include Rheumatoid factor, Cryoglobulins, Protein electrophoresis, Antinuclear Ab, Hepatitis B serology, Hepatitis C serology, and HIV testing.

Systemic necrotising

Clinical assessment. Antineutrophil cytoplasmic Ab and complement assist in the differentiation of Polyarteritis nodosa, and other vasculitides, from ANCA positive vasculitides that involve a broader range of vessels.

Polyarteritis nodosa


Microscopic polyangiitis


Granulomatosis with polyangiitis


Mucocutaneous lymph node syndrome (Kawasaki's disease)


Churg-Strauss syndrome


Small vessel, including leucocytoclastic


Drug reaction, especially

  • Frusemide
  • Thiazides
  • Allopurinol


Connective tissue diseases, especially 

  • Rheumatoid arthritis
  • SLE


Henoch-Schonlein purpura

See also Glomerulonephritis (GN)



Large vessel, especially


Giant cell arteritis


  • Temporal arteritis


Thrombo-angiitis obliterans (Buerger's disease)


Takayasu's disease


Erythema nodosum


Behcet's syndrome


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