Waldenström's macroglobulinaemia (WM), lymphoplasmacytic lymphoma, is an indolent lymphoid neoplasm, which occurs mainly in older patients.
It is characterised by the presence of an IgM paraprotein and a bone marrow infiltrate with monoclonal plasmacytoid lymphocytes.
Hyperviscosity and progressive bone marrow failure are common complications of WM.
Full blood count, Blood film, White cell count differential, Erythrocyte sedimentation rate, Bone marrow biopsy (bone marrow aspiration/trephine biopsy), Protein, Albumin, Protein electrophoresis, Paraprotein typing (and quantitation), Immunoglobulins (G, A, M).
See also Lymphoma (classification), Lymphoproliferative disorders and Paraproteinaemia