The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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10 mL blood in chilled EDTA tube - plasma separated and frozen immediately.
Cessation of diuretics or antihypertensive drugs at least two weeks prior to testing is preferred.
Peripheral venous (plasma) renin is usually assayed in conjunction with aldosterone. The aldosterone/renin ratio is calculated.
Dependent on sodium intake, posture, drugs including ACE inhibitors and diuretics.
Investigation of hypertension when primary Hyperaldosteronism (Conn’s syndrome) is suspected, this is commonly but not invariably associated with Hypokalaemia.
Documentation of Hyperaldosteronism in the investigation of suspected renovascular Hypertension.
The plasma aldosterone/renin ratio is of greater diagnostic value than either test alone.
A high aldosterone/renin ratio suggests mineralocorticoid excess (primary hyperaldosteronism).
Elevation of both aldosterone and renin to a similar extent suggests a renal abnormality (secondary hyperaldosteronism). The result should be interpreted in consultation with the pathologist.
Veglio F et al. Minerva Med 2003; 94: 259-265.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
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