Bence Jones protein urine
Keywords: Protein electrophoresis urine, Urine EPG, Paraprotein typing urine
Random urine specimen; 24 h urinary collection preferred.
Protein electrophoresis on urine.
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Depends on laboratory.
Investigation of monoclonal gammopathies, hypogammaglobulinaemia, and suspected Plasma cell myeloma.
Performed in conjunction with Protein electrophoresis (serum).
Monoclonal free light chain proteinuria (Bence Jones proteinuria) is seen in patients with light chain myeloma (where there is a monoclonal expression of the light chain without a coexisting heavy chain), in approximately 50% of those with IgG and IgA myeloma, and in some patients with other Lymphoproliferative disorders (e.g. macroglobulinaemia) and plasma cell dyscrasias (Amyloidosis).
Intact paraprotein molecules may also be detected in serum.
Urine protein dipsticks do not detect Bence Jones protein.
See Free light chains.
Beetham R. Ann Clin Biochem 2000; 37: 563-570.