Bence Jones protein urine

Keywords: Protein electrophoresis urine, Urine EPG, Paraprotein typing urine


Random urine specimen; 24 h urinary collection preferred.


Protein electrophoresis on urine.

Reference Interval:

Depends on laboratory.


Investigation of monoclonal gammopathies, hypogammaglobulinaemia, and suspected Plasma cell myeloma.

Performed in conjunction with Protein electrophoresis (serum).


Monoclonal free light chain proteinuria (Bence Jones proteinuria) is seen in patients with light chain myeloma (where there is a monoclonal expression of the light chain without a coexisting heavy chain), in approximately 50% of those with IgG and IgA myeloma, and in some patients with other Lymphoproliferative disorders (e.g. macro­globulinaemia) and plasma cell dyscrasias (Amyloidosis).

Intact paraprotein molecules may also be detected in serum.

Urine protein dipsticks do not detect Bence Jones protein.

See Free light chains.


Beetham R. Ann Clin Biochem 2000; 37: 563-570.

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