The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Keywords: BHCG titre, Human chorionic gonadotropin quantitative, QHCG, Beta human chorionic gonadotropin, Pregnancy test, hCG, Human chorionic gonadotropin (beta subunit), Chorionic gonadotropin
5 mL blood in a plain or lithium heparin tube.
Random urine (early morning is best) may be acceptable for a qualitative test.
Immunoassay - qualitative or quantitative.
< 5 mIU/L (non-pregnant).
The reference interval in pregnancy varies with gestational age.
Qualitative test: diagnosis of pregnancy including ectopic pregnancy.
Quantitative test: diagnosis of threatened abortion or ectopic pregnancy (sequential tests may be needed).
Monitoring hCG-producing tumours (eg, hydatidiform mole, uterine choriocarcinoma, gonadal and extragonadal germ cell tumours): an assay that detects the free β subunit as well as the whole molecule is required and is also suitable for pregnancy-related applications. However, it should be noted that most commercial assays are not licensed for malignancy, as malignancy may produce variant hCG species.
If pregnancy occurs the test becomes positive 6-10 days following ovulation.
The normal doubling time for the hormone in early pregnancy is 36 hours. Low levels for gestational age and/or a low rate of increase may indicate threatened abortion or ectopic pregnancy.
High levels for gestational age may indicate molar pregnancy.
Increased levels in a patient with a history of an hCG-producing tumour indicate residual or recurrent tumour.
Duffy MJ. Crit Rev Clin Lab Sci 2001; 38: 225-262.
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Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
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