The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Keywords: BHCG titre, Human chorionic gonadotropin quantitative, QHCG, Beta human chorionic gonadotropin, Pregnancy test, hCG, Human chorionic gonadotropin (beta subunit), Chorionic gonadotropin
5 mL blood in a plain or lithium heparin tube.
Random urine (early morning is best) may be acceptable for a qualitative test.
Immunoassay - qualitative or quantitative.
< 5 mIU/L (non-pregnant).
The reference interval in pregnancy varies with gestational age.
Qualitative test: diagnosis of pregnancy including ectopic pregnancy.
Quantitative test: diagnosis of threatened abortion or ectopic pregnancy (sequential tests may be needed).
Monitoring hCG-producing tumours (eg, hydatidiform mole, uterine choriocarcinoma, gonadal and extragonadal germ cell tumours): an assay that detects the free β subunit as well as the whole molecule is required and is also suitable for pregnancy-related applications. However, it should be noted that most commercial assays are not licensed for malignancy, as malignancy may produce variant hCG species.
If pregnancy occurs the test becomes positive 6-10 days following ovulation.
The normal doubling time for the hormone in early pregnancy is 36 hours. Low levels for gestational age and/or a low rate of increase may indicate threatened abortion or ectopic pregnancy.
High levels for gestational age may indicate molar pregnancy.
Increased levels in a patient with a history of an hCG-producing tumour indicate residual or recurrent tumour.
Duffy MJ. Crit Rev Clin Lab Sci 2001; 38: 225-262.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
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