The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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5 mL blood in plain tube.
< 5 mg/L.
For high sensitivity assays (hs-CRP):
Low risk: < 1.0 mg/L
Average risk: 1.0-3.0 mg/L
Assessment of acute phase reaction in inflammatory, infective and neoplastic disorders;
monitoring disease activity, particularly in inflammatory arthritis;
monitoring patients after premature rupture of the membranes, for developing infection; and
assessment of risk factors for Myocardial infarction (hs-CRP).
Marginally raised hs-CRP, and values within the normal range, have been demonstrated to be an independent risk factor for coronary artery disease. However, the applicability of measuring serum CRP for screening in asymptomatic populations for coronary artery disease risk remains unclear.
Elevation indicates acute phase response or active disease in chronic inflammatory disorders.
CRP is a more sensitive early indicator of an acute phase response than the ESR. It also returns towards normal more rapidly with improvement or resolution of the disease process. The test is less sensitive than the ESR for some disorders eg, ulcerative colitis, SLE.
In patients at risk for Myocardial infarction, and without other causes of an acute phase response, the presence of slightly elevated or even high normal hs-CRP indicates a greater risk of myocardial infarction. The use of high sensitivity CRP in clinical practice remains undecided.
See also Erythrocyte sedimentation rate and Acute phase reactants.
Young B et al. Pathology 1991; 23: 118-124.
Jialal I and Devaraj S. Am J Clin Pathol 2001; 116: 108-115.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
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