The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Keywords: CK isoenzyme MB, Creatine kinase MB isoenzyme, Creatine kinase isoenzymes
5 mL blood in lithium heparin or plain tube.
Immunoassay, electrophoresis, spectrophotometry.
0-10 U/L; 0-5% of the total CK (enzyme activity)
0-6 mg/L (immunoassay).
This test has been superseded by cardiac Troponin T or Troponin I for the diagnosis of Myocardial infarction.
CKMB elevation takes about four hours to develop after Myocardial infarction, and levels usually return to normal within 48 hours.
Elevation of total CK, and CKMB as a percentage of CK, indicates a myocardial origin of CK. If the total CK is <100 U/L, elevation of CKMB (as a percentage of CK) is unreliable as an indicator of Myocardial infarction.
There is <5% CKMB in skeletal muscle, so although skeletal muscle disease or damage may cause an increase in total CKMB, the level will be <5% of total CK.
Adams JE et al. Clin Chem 1994; 40(1): 1291-1295.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
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