The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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5 mL blood in lithium heparin or plain tube.
0-30 days: 0.05-0.30 g/L
1-12 months: 0.15-0.45 g/L
1-16 yrs: 0.22-0.50 g/L
Adults: 0.24-0.60 g/L
Suspected Wilson's disease, Menkes disease. Urinary and hepatic copper are more reliable tests for Wilson's disease.
Low levels are found in Wilson's disease but a normal level does not exclude this diagnosis. The molar copper/caeruloplasmin ratio is increased in Wilson's disease due to increased albumin-bound copper.
Decreased caeruloplasmin levels occur in liver failure and in Menkes disease (where the copper/cearuloplasmin ratio is decreased).
Idiopathic hypocaeruloplasminaemia occurs as a non-pathogenic genetic variant but acaeruloplasminemia causes massive iron overload.
Increased levels may occur in pregnancy and in patients on oestrogen therapy. Levels are increased by oestrogens, in an acute phase response and in liver disease and this may mask a deficiency state.
See also Copper and Copper urine.
Ferenci P et al. Liver Int 2003; 23: 139-142.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
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