The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Keywords: Pentagastrin stimulation test
5 mL blood in lithium heparin or plain tube.
Females: < 5 ng/L
Males: < 12 ng/L
0 - 6 months: < 40 ng/L
6 months - 3yrs: < 15 ng/L
Over 3 years, values similar to adults.
Diagnosis of medullary carcinoma of the thyroid, including investigation of asymptomatic family members at risk for multiple endocrine neoplasia 2 (when an underlying mutation has not been identified).
Follow-up of patients with medullary carcinoma after surgery.
Elevated in medullary carcinoma of the thyroid. Levels may be increased prior to clinical evidence of a lump.
In doubtful cases a pentagastrin stimulation test is done Pentagastrin 0.5 µg/kg is given intravenously.
Levels increase in medullary carcinoma of the thyroid but remain unchanged in normals.
Molecular genetics: testing for mutation in the ret oncogene, is more reliable for identification of MEN type 2 syndromes.
Cohen R et al. Ann Med Intern 2003; 154: 109-116.
Basuyau JP et al. Clin Chem 2004; 50: 1828-1830.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
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