The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Keywords: Cardiolipin antibody, Anticardiolipin antibody, ACA
5 mL blood in plain tube.
May differ between laboratories.
Investigation of patients with clinical features suggestive of the Phospholipid antibody syndrome (especially recurrent unexplained venous or arterial thrombosis, fetal loss, thrombocytopenia) alone or in association with SLE or other connective tissue disorder.
Moderate to high levels of IgG cardiolipin antibody are seen in the Phospholipid antibody syndrome, but the antibody may also be detected in SLE, other autoimmune disorders, some infections (eg, Syphilis) and with some drugs. Persistent antibodies detectable after 12 weeks are more likely to be associated with anti phospholipid antibody syndrome.
Cardiolipin antibodies are associated with the lupus inhibitor, beta-2-glycoprotein1 antibodies, and with false positive syphilis serology.
Levels may fluctuate spontaneously with time. A positive result in the absence of clinical history has limited significance.
See also Lupus anticoagulant.
Levine JS et al. N Engl J Med 2002; 346(10): 752-763.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
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