The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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24 h urine collection with HCl as preservative.
Adrenaline: < 80 nmol/24 h
Noradrenaline: < 780 nmol/24 h
Dopamine: < 3,500 nmol/24 h
For Phaeochromocytoma, Free metanephrines (plasma) or urine fractionated metanephrines (Metanephrines urine) are the preferred screening tests.
Diagnosis of Phaeochromocytoma (increased urine adrenaline and/or urine noradrenaline); diagnosis of Neuroblastoma and ganglioneuroma (increased dopamine).
Excretion of urinary adrenaline and noradrenaline is usually increased in Phaeochromocytoma, particularly after a hypertensive paroxysm.
Excretion may also be increased in malignant hypertension and with severe stress.
Some drugs (eg, labetalol) may interfere in some assays - consult pathologist.
See also Catecholamines, 4-hydroxy-3-methoxymandelate, Homovanillic acid urine, Free metanephrines, Metanephrines urine and Clonidine suppression test.
Gerlo EAM and Sevens C. Clin Chem 1994; 40: 250-256.
Sawka AM et al J Clin Endocrinol Metab 2003; 88(2): 553-558.
Eisenhofer G, Peitzsch M. Clin Chem 2014; 60: 1486-1499.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
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