Collagen crosslink fragments
Morning fasting 2nd void spot urine or blood.
Results urine NTX or DPD, or plasma CTX are expressed as a ratio with creatinine.
|Reference Interval:|| |
Depends on method.
Diagnosis and monitoring of conditions with increased bone collagen breakdown, especially monitoring of treatment in patients with postmenopausal Osteoporosis and Paget's disease of the bone.
CTX, DPD and NTX are specific for bone collagen.
If levels are increased it indicates an increase of bone breakdown.
Vasikaran S et al. Osteoporosis Int 2011;22(2):391-420