The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Keywords: Complement CH50, Complement CH100
10 mL blood in plain tube.
The specimen should be placed on melting ice and transported immediately to the laboratory.
ELISA
Lysis of haemolysin-treated sheep red cells in solution or agarose.
CH50 is a tube method, measuring 50% cell lysis. CH100 is a screening plate method measuring 100% cell lysis.
Consult pathologist.
A screening test for patients with suspected inherited complement component deficiency. The tests are of no value in monitoring complement activation in acquired disorders eg, SLE.
Incorrect specimen collection is the most common cause of reduced levels. Reduced levels may also indicate deficiency in one of the components of complement. Levels will be variably reduced in acquired disorders associated with complement activation.
Ruddy S. In: Rose NR et al eds. Manual of Clinical Laboratory Immunology. 4th ed. ASM Press 1997.
Wen L et al. Journal of Allergy and Clinical Immunology. 2004; 113: 585-93.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
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