The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Keywords: CK, Creatine phosphokinase, CPK, Aldolase
5 mL blood in lithium heparin or plain tube.
Influenced by gender and method; local laboratory reference intervals should be ascertained. Typically:
Neonate: 70-380 U/L
Adult female: 30-180 U/L
Adult male: 60-220 U/L.
Historical test for the diagnosis and monitoring of Myocardial infarction. CKMB with CKMB/CK ratio is more specific, but has been superseded by cardiac Troponin T or Troponin I.
Levels of CK are increased in diseases affecting skeletal muscle. It can be used to detect carrier status for Duchenne muscular dystrophy, although not all carriers have increased levels.
Elevation of CK with CKMB as > 5% percent of CK, indicates a myocardial origin of CK. CK levels may also be increased with skeletal muscle injury (eg, after intramuscular injection or excessive exercise), in myositis, myopathy, rhabdomyolysis or Hypothyroidism.
Elevation of no pathological significance is seen in patients with a 'macro-CK' (a complex of CK with an immunoglobulin).
Isoenzyme studies may be useful in investigating increased CK activities of uncertain cause.
French JK, White HD. Clinical implications of the new definition of myocardial infarction. Heart. 2004 Jan;90(1):99-106. Review.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
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