The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Keywords: Cr clearance
Serum and timed urine collection for creatinine measurements; see Creatinine urine.
The patient should not eat meat at the meal immediately prior to, or during, the procedure.
A calculated value using serum and urine creatinine.
Creatinine clearance (mL/min) = urine creatinine (mmol/L) x urine volume (mL) x 16.7 / plasma creatinine (mmol/L) x duration of collection (hours) The patient's height and weight may be measured so that surface area can be calculated and creatinine clearance adjusted to the 'standard' body surface area of 1.73m2 if required.
Creatinine clearance may be estimated rather than measured -see Creatinine clearance Cockcroft and Gault.
Normal > 70 mL/min in a young adult. Typically falling approx 0.5 mL/min per year at ages over 30 years.
Creatinine clearance is a marker of glomerular filtration rate (GFR). Measured creatinine clearance is of particular use in patients with extremes of body size or composition where estimation formulae may be unreliable.
Reduced creatinine clearance is an indicator of reduced glomerular filtration rate (GFR). This may indicate acute or chronic kidney disease. Doses of some drugs may need to be adjusted.
Complete and accurately timed urine collections are essential.
Australian Medicines Handbook
Tietz Textbook of Clinical Biochemistry
Cockcroft DW and Gault MH. Nephron 1976 16: 31-41.
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Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
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