The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Keywords: Cytomegalovirus antibody, Cytomegalovirus serology, CMV antibody, CMV serology, CMV
5-10 mL blood. Acute and convalescent (2 weeks) specimens are required.
Mononucleosis syndrome (with negative Epstein-Barr virus serology); acute hepatitis (after exclusion of HAV, HBV, HCV infection); possible congenital CMV infection;
screening of blood transfusion donors, donor and recipient before transplantation; and evaluation of patients with HIV infection.
IgG seroconversion from negative to positive is a reliable indicator of primary infection.
A stable positive result for total or IgG antibodies indicates past infection.
A 4-fold or greater rise in IgG usually represents recent infection, often due to reactivation or reinfection. However, this should be confirmed by viral detection, since 4-fold fluctuations in titre may occur in healthy individuals.
Detection of IgM antibody can indicate recent infection but is not always a reliable indicator as IgM can persist for long periods.
IgG avidity determination may be used if diagnosis of acute primary infection is critical eg in early pregnancy.
In a neonate, the presence of IgM indicates intrauterine infection.
Revello MG and Gerna G. Clin Microbiol Rev 2002; 15: 680-715.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
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